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"As more research is conducted into patient groups and their influence in medicine, the question remains - are they engaging in potentially deceptive practices by suggesting solutions which better serve the interests of their corporate sponsors, rather than what's best for patients?" said Professor Bero, who is also based at the University of Sydney's Faculty of Pharmacy . "The very way we think about disease is being subtly distorted because many of the ostensibly independent players, including patient advocacy groups, are largely singing tunes acceptable to companies seeking to maximise markets for drugs and devices." Currently in Australia there are no national requirements for patient advocacy groups to disclose their funding sources or industry sponsorships, though some pharmaceutical companies voluntarily disclose payments to these organisations through Medicines Australia. Professor Bero and Dr Moynihan point to an increasing body of evidence suggesting bias in favour of funding source by those patient advocacy groups sponsored by drug manufacturers and other device companies. A new survey by Dr Susannah Rose and colleagues from the Cleveland Clinic in the United States of 439 patient organisations found that two-thirds of responding groups received some form of industry funding. One in 10 reported half their funding was from industry, with the median amount $50,000, while approximately 10 percent of groups received $1 million annually - almost half of that from pharmaceutical and device companies. Some of these groups even reported that they felt pressure from their sponsors to conform to their positions or interests. "While there is ample evidence across medicine more generally showing that funding has the potential to bias research, education and practice, there is limited data on the possibility of similar associations between industry funding and advocacy group positions or activities," the authors state. "In our view this new [research] demonstrates an urgent need for patient advocacy organisations to explicitly focus much more on representing the interests of patients and citizens, rather than serving - inadvertently or otherwise - the interests of their industry sponsors." Another new study led by Dora Lin from the Johns Hopkins Bloomberg School of Public Health reveals that manufacturer-sponsored groups were more likely to oppose draft guidelines aimed at increasing regulation of opioid use (38 percent) compared to those with commercial mortgage no industry funding (six percent). The study also revealed that of the 45 groups receiving industry funding, none of these were disclosed in the funding comments as part of the guideline submission. "Thousands of patient advocacy groups in the United States are reliant on support from pharmaceutical or device industries, and at the system level the aggregation of this influence raises substantial concerns," said Dr Ray Moynihan of Bond University's Centre for Research in Evidence-Based Practice (CREBP).

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